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KMID : 0369820050350040249
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Jorunal of Korean Pharmaceutical Sciences
2005 Volume.35 No. 4 p.249 ~ p.254
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Effect of Natural Compounds on P-glycoprotein Activity in Human Uterine Sarcoma Cells
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정수연/Chung SY
고은정/김나형/성민경/장정옥/이화정/Go EJ/Kim NH/Sung MK/Jang JO/Lee HJ
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Abstract
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Multidrug resistance (MDR) of cancer cells is, at least in part, associated with the overexpression of P-glycoprotein (P-gp). Many studies have demonstrated that natural compounds obtained from fruits, vegetables, teas and medicinal plants may modulate P-gp activity. The objective of the present investigation was to examine the effect of seven natural compounds on the P-gp activity in human uterine sarcoma cell line, MES-SA/DX5. Daunomycin uptake was significantly increased by biochanin A and silymarin (p<0.0001) whereas it was reduced by morin (p<0.01). The efflux of daunomycin from the cells was significantly inhibited by biochanin A, morin, cephalotaxine, berberine (p<0.05) and silymarin (p<0.0001). Biochanin A, berberine and silymarin significantly decreased IC50 value of daunomycin (p<0.05) while morin increased it (p<0.05). These results suggest that some natural compounds such as biochanin A and silymarin may inhibit P-gp function and can be developed as MDR reversing agents to improve the efficacy of chemotherapeutic drugs when administered concomitantly.
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KEYWORD
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P-glycoprotein, Natural compounds, Daunomycin, MES-SA/DX5 cells, Multidrug resistance
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